Sex-specific cut-off for dilute Russell's viper venom time lupus anticoagulant test may be of value.

ABSTRACT:

Background

Current guidelines recommend application of the 99th percentile to determine the cut-off value on at least 120 healthy donors regardless of sex for lupus anticoagulant (LA) ratio of each step. However, a statistically significant difference between the sexes has been found for LA ratio recently.

Objectives

To clarify whether this sex difference in dilute Russell's viper venom time (DRVVT) exists in various detection systems and the necessity of setting sex-specific cut-off values.

Methods

Blood samples from healthy donors were detected on 3 DRVVT detection systems, and the sex-specific cut-offs of DRVVT test were obtained based on the 99th or 97.5th centile of screen, confirm, and normalized ratios (NRs) grouped by sex in each system. One thousand one hundr

SUBMITTER: Tang N 

PROVIDER: S-EPMC11741938 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature