Petroleum ether extract of Elephantopus mollis induces senescence and inhibits invasion in breast cancer MDA-MB-231 cells.

ABSTRACT: Elephantopus mollis Kunth H.B et Kunth is an herbal plant employed customarily for the treatment of numerous maladies, notably cancers. Here in this research, we studied the effects of E. mollis (EM) petroleum ether extract (EM-PE) on the highly aggressive breast cancer cell line MDA-MB-231. The result from phytochemical analysis demonstrated the presence of tannins and saponins in EM-PE, of which, saponins made up more than 50% of the extract's mass. Cytotoxicity results, which were obtained from MTT assay and microscopic observation, suggested the potential of EM-PE to inhibit the growth of MDA-MB-231 cells with low IC₅₀ value (approximately 30 μg/mL) and remarkably high selectivity index (> 4.78). Further evaluation indicated that EM-PE inhibited MDA-MB-2

SUBMITTER: Long TT 

PROVIDER: S-EPMC11741969 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature