Intravenous Immunoglobulin Therapy for Pyoderma Gangrenosum: A Multicenter Retrospective Analysis in 81 Patients.

ABSTRACT:

Background

Pyoderma gangrenosum (PG) is rare neutrophil skin disease causing painful, progressively enlarging ulcers. Among the treatment options, intravenous immunoglobulin (IVIG) is a therapy of first choice for paraneoplastic PG. Otherwise, it is used in therapy-refractory courses.

Objective

To assess the efficacy and safety of IVIG therapy in patients with PG.

Methods

A retrospective chart review for patients in five dermatologic wound centres in Germany was performed.

Results

Overall, 81 patients were included. IVIG was used as adjunct therapy with (methyl-) prednisolone and/or a steroid sparing therapy in 77 (95.1%) cases. Response to treatment (combined complete and partial, defined as tendency to heal and cessation of lesion progression, respectively) w

SUBMITTER: Ronicke M 

PROVIDER: S-EPMC11741994 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature