Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent and lethal malignancies worldwide. Despite progress in immunotherapy for cancer treatment, its application and efficacy in ESCC remain limited. Therefore, there is an ongoing need to explore potential molecules and therapeutic strategies related to tumor immunity in ESCC.

Methods

In this study, we integrated high-throughput sequencing data, gene chip data, single-cell sequencing data, and various bioinformatics analysis methods along with experimental approaches to identify key genes involved in immune infiltration in ESCC and investigate their relationship with immune cell development, as well as the potential of these key genes in immunotherapy.

Results

We discovered and validated a po

SUBMITTER: Huang T 

PROVIDER: S-EPMC11742006 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature