<i>Salmonella</i>-induced cholesterol accumulation in infected macrophages suppresses autophagy via mTORC1 activation.

ABSTRACT: Salmonella enterica serovar Typhimurium is a Gram-negative bacillus that infects the host intestinal epithelium and resident macrophages. Many intracellular pathogens induce an autophagic response in host cells but have evolved mechanisms to subvert that response. Autophagy is closely linked to cellular cholesterol levels; mTORC1 senses increased cholesterol in lysosomal membranes, leading to its hyperactivity and suppression of autophagy. Previous studies indicate that Salmonella infection induces dramatic accumulation of cholesterol in macrophages, a fraction of which localizes to Salmonella containing vacuoles (SCVs). We previously reported that the bacterial effector protein SseJ triggers cholesterol accumulation through a signaling cascade involving focal adhesion

SUBMITTER: Torsilieri HM 

PROVIDER: S-EPMC11742112 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature