TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1⁺ adult-born dentate granule cells.

ABSTRACT: Aberrant adult hippocampal neurogenesis is implicated in neurological and mood disorders associated with dysregulation of the mechanistic target of rapamycin (mTOR). Understanding how the mTOR pathway shapes the functional development of different subpopulations of adult-born hippocampal neural stem cells will enable insight into potential therapeutic pathways for these disorders. Here we study how loss of TSC2, a regulator of mTOR pathway and a causal gene for tuberous sclerosis complex (TSC), affects dentate gyrus granule cell morphogenesis and hippocampal-dependent function. We found that Tsc2^KO mice with TSC2 specifically ablated from Gli1⁺ adult-born neural stem cells showed neuronal hypertrophy, reduced NEUN expression, increased dendritic arborization, p

SUBMITTER: Kowalczyk M 

PROVIDER: S-EPMC11742115 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature