Gender differences in the prognostic impact of uric acid in patients with heart failure and preserved ejection fraction.

ABSTRACT:

Background

Uric acid has been identified as an independent predictor of poor outcomes in patients with heart failure with preserved ejection fraction (HFpEF). However, the impact of gender differences on this association is not fully explored.

Methods

This retrospective cohort study included hospitalized patients with HFpEF from June 2018 to October 2022. The primary outcome was a composite endpoint, defined as the occurrence of all-cause mortality and heart failure readmission. Kaplan-Meier survival analysis and stratified Cox regression examined the combined effect of gender and uric acid on the composite endpoint, and restricted cubic spline curves were applied to visualize the relationship.

Results

The study included 547 patients, with 267 females and 280 males. I

SUBMITTER: Wu X 

PROVIDER: S-EPMC11742201 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature