High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings.

ABSTRACT: Optically transparent neural microelectrodes have facilitated simultaneous electrophysiological recordings from the brain surface with the optical imaging and stimulation of neural activity. A remaining challenge is to scale down the electrode dimensions to the single-cell size and increase the density to record neural activity with high spatial resolution across large areas to capture nonlinear neural dynamics. Here we developed transparent graphene microelectrodes with ultrasmall openings and a large, transparent recording area without any gold extensions in the field of view with high-density microelectrode arrays up to 256 channels. We used platinum nanoparticles to overcome the quantum capacitance limit of graphene and to scale down the microelectrode diameter to 20 µm. An interlayer-

SUBMITTER: Ramezani M 

PROVIDER: S-EPMC11742260 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature