Phenotyping <i>in vivo</i> chronic inflammation in multiple sclerosis by combined ¹¹C-PBR28 MR-PET and 7T susceptibility-weighted imaging.

ABSTRACT:

Background

¹¹C-PBR28 positron emission tomography (PET), targeting the translocator protein, and paramagnetic rim lesions (PRL) have emerged as promising imaging markers of MS chronic inflammation. No consensus on which is the optimal marker exists.

Objectives

To investigate the ability of ¹¹C-PBR28 PET and PRL assessment to identify chronic inflammation in white matter (WM) MS lesions and their relation to neurological impairment.

Methods

Based on ¹¹C-PBR28 uptake, brain WM lesions from 30 MS patients were classified as PET active or inactive. The PRL presence was assessed on 7T phase reconstructions, T1/T2 ratio was calculated to measure WM microstructural integrity.

Results

Less than half (44%) of non-PRL WM lesions were acti

SUBMITTER: Treaba CA 

PROVIDER: S-EPMC11742271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature