Role of GLCCI1 in inhibiting PI3K-induced NLRP3 inflammasome activation in asthma.

ABSTRACT:

Background

Glucocorticoid-induced transcript 1 (GLCCI1) has been reported to be associated with the efficiency of inhaled glucocorticoids in patients with asthma. This study aimed to investigate the role of GLCCI1 in the regulation of nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) by the phosphatidylinositol 3-kinase (PI3K) pathway in the pathogenesis of allergic asthma.

Methods

The expression levels of genes encoding GLCCI1, NLRP3 inflammasome components, and PI3K pathway-related indicators were detected in cells isolated from induced sputum from patients with asthma and healthy controls. Next, we induced asthma in wild-type C57BL/6 mice and Glcci1 knockout (Glcci1 ^-/-) mice by injecting

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11742361 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature