Evolution of the umbilical cord blood proteome across gestational development.

ABSTRACT: Neonatal health is dependent on early risk stratification, diagnosis, and timely management of potentially devastating conditions, particularly in the setting of prematurity. Many of these conditions are poorly predicted in real-time by clinical data and current diagnostics. Umbilical cord blood may represent a novel source of molecular signatures that provides a window into the state of the fetus at birth. In this study, we comprehensively characterized the cord blood proteome of infants born between 25 to 42 weeks using untargeted mass spectrometry and functional enrichment analysis. We determined that the cord blood proteome at birth varies significantly across gestational development. Proteins that function in structural development and growth (e.g., extracellular matrix organization,

SUBMITTER: Mithal LB 

PROVIDER: S-EPMC11742406 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature