Altered immune surveillance of B and T cells in patients with persistent residual lung abnormalities 12 months after severe COVID-19.

ABSTRACT:

Background

Post-COVID-19 respiratory sequelae often involve lung damage, which is called residual lung abnormalities, and potentially lead to chronic respiratory issues. The adaptive immune response, involving T-cells and B-cells, plays a critical role in pathogen control, inflammation, and tissue repair. However, the link between immune dysregulation and the development of residual lung abnormalities remains unclear.

Methods

109 patients discharged with residual lung abnormalities after a critical COVID-19 were followed for 12 months and divided as full recovery patients (FRG, n = 88) and persistent lung abnormalities (PLAG, n = 21). Cell profiling analysis was done using flow cytometry at 24 h of not antigen-specific in vitro stimulation. Plasma or supernatant levels of IF

SUBMITTER: Flores-Gonzalez J 

PROVIDER: S-EPMC11742501 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature