Lymphopenia predicts poor outcomes in newly diagnosed multiple myeloma.

ABSTRACT:

Abstract

Bone marrow microenvironment plays an important role in promoting growth and survival of multiple myeloma (MM) cells. The tumor-promoting immune microenvironment is augmented while antitumor immune responses are inhibited. Although clinical and genomic markers of high-risk MM have been described, the immune status is just being recognized as a potential mediator of disease behavior. This is even more important with the development of a number of immune-based therapies. Based on these considerations, we evaluated peripheral blood absolute lymphocyte count (ALC) as an easily accessible marker representing immune microenvironment at diagnosis and after treatment of MM. We retrospectively evaluated 11 427 patients diagnosed with MM between 2000 and 2019 at Veterans Administrat

SUBMITTER: Ferri GM 

PROVIDER: S-EPMC11742561 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature