Bioinformatics and Gene Expression Omnibus Analysis of Key Candidate Genes and Pathways Associated with Femoral Head Necrosis.

ABSTRACT:

Background

Femoral head necrosis (FHN) is a debilitating bone disease affecting an estimated 8 million people worldwide. Although specific drugs for FHN have limitations, targeted therapies have shown promising results. The significance of this study is underscored by the high prevalence of FHN, the limitations of current treatments, and the potential of targeted drugs and natural compounds for effective therapeutic interventions.

Objectives

This study aimed to explore the genetic landscape and associated pathways of FHN through bioinformatics analysis of Gene Expression Omnibus (GEO) data and molecular docking simulations targeting specific enzymes implicated in FHN.

Methods

Differentially expressed genes (DEGs) in FHN samples were identified from GEO datasets, speci

SUBMITTER: Ding Y 

PROVIDER: S-EPMC11742569 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature