Imaging blood-brain barrier dysfunction in drug-resistant epilepsy: A multi-center feasibility study.

ABSTRACT:

Objective

Blood-brain barrier dysfunction (BBBD) has been linked to various neurological disorders, including epilepsy. This study aims to utilize dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to identify and compare brain regions with BBBD in patients with epilepsy (PWE) and healthy individuals.

Methods

We scanned 50 drug-resistant epilepsy (DRE) patients and 58 control participants from four global specialized epilepsy centers using DCE-MRI. The presence and extent of BBBD were analyzed and compared between PWE and healthy controls.

Results

Both greater brain volume and higher number of brain regions with BBBD were significantly present in PWE compared to healthy controls (p < 10^-7). No differences in total brain volume with BBBD were obs

SUBMITTER: Cafri N 

PROVIDER: S-EPMC11742632 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature