Prefrontal cortex synchronization with the hippocampus and parietal cortex is strategy-dependent during spatial learning.

ABSTRACT: During spatial learning, subjects progressively adjust their navigation strategies as they acquire experience. The medial prefrontal cortex (mPFC) supports this operation, for which it may integrate information from distributed networks, such as the hippocampus (HPC) and the posterior parietal cortex (PPC). However, the mechanism underlying the prefrontal coordination with HPC and PPC during spatial learning is poorly understood. Here we show that during navigation trials, mice displayed two sequential behavioral stages: searching and exploration. Exclusively during searching, mice gradually increased their efficiency by transitioning from non-spatial to spatial strategies. When mice used spatial strategies specifically in searching stage, hippocampal and parietal oscillations synchronized

SUBMITTER: Garcia F 

PROVIDER: S-EPMC11742664 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature