Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders.

ABSTRACT: Histological chorioamnionitis (HCA) is a form of maternal immune activation (MIA) linked to an increased risk of neurodevelopmental disorders in offspring. Our previous study identified neurodevelopmental impairments in an MIA mouse model mimicking HCA. Thus, this study investigated the role of CD11c⁺ microglia, key contributors to myelination through IGF-1 production, in this pathology. In the mouse model, the CD11c⁺ microglial population was significantly lower in the MIA group than in the control group on postnatal day 3 (PN3d). Furthermore, myelination-related protein levels significantly decreased in the MIA group at PN8d. In humans, preterm infants with HCA exhibited higher IL-6 and IL-17A cord-serum levels and lower IGF-1 levels than those without HCA, followed

SUBMITTER: Fuma K 

PROVIDER: S-EPMC11742679 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature