Pig nasal and rectal microbiotas are involved in the antibody response to Glaesserella parasuis.

ABSTRACT: Vaccination stands as one of the most sustainable and promising strategies to control infectious diseases in animal production. Nevertheless, the causes for antibody response variation among individuals are poorly understood. The animal microbiota has been shown to be involved in the correct development and function of the host immunity, including the antibody response. Here, we studied the nasal and rectal microbiota composition in association with the antibody response against the pathobiont Glaesserella parasuis. The nasal and rectal microbiotas of 24 piglets were sampled in two farms before vaccination and in one unvaccinated farm (naturally exposed to the pathobiont) at similar time. Microbiota composition was inferred by V3V4 16S rRNA gene sequencing and bioinformatics analysis, and

SUBMITTER: Obregon-Gutierrez P 

PROVIDER: S-EPMC11742689 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature