The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective cohort study.

ABSTRACT:

Background

The impacts of early-life tobacco smoke exposure, including exposure during pregnancy and the initiation of smoking during childhood and adolescence, on cognitive decline and the risk of dementia in later life have not been investigated.

Methods

We used data from the UK Biobank (UKB) to assess early-life tobacco exposure, including in utero exposure and the age at which smoking was initiated. Cox proportional-hazards regression models were employed to gauge the relationships between early-life tobacco smoke exposure and both the risk of cognitive decline and dementia in adulthood. We adjusted for potential confounding factors, including age, gender, race, household income, alcohol consumption status, physical activity, family history of dementia, education level,

SUBMITTER: Lin C 

PROVIDER: S-EPMC11742755 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature