Expression and prognostic value of ferritinophagy-related NCOA4 gene in low-grade glioma: integration of bioinformatics and experimental validation.

ABSTRACT:

Background

Low-grade glioma (LGG) is a primary brain tumor with relatively low malignancy. NCOA4 is a key regulator of ferritinophagy-related processes and is involved in the occurrence and development of many cancers. However, the role of NCOA4 in LGG remains poorly understood.

Methods

This study comprehensively analyzed several mainstream bioinformatics databases to explore the expression, diagnostic efficacy, clinical pathological features, immune infiltration, prognostic value, and biological functions of NCOA4 in LGG. Immunohistochemistry experiments were conducted using LGG tissue samples collected from our hospital to validate the bioinformatics analysis results.

Results

NCOA4 expression was significantly elevated in LGG (p < 0.05), with an Area Under the Recei

SUBMITTER: Chen G 

PROVIDER: S-EPMC11742756 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature