Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures.

ABSTRACT:

Background

Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with a population prevalence of 1/7000 births. TSC manifests behaviorally with features of autism, epilepsy, and intellectual disability. Resting state electroencephalography (EEG) offers a window into neural oscillatory activity and may serve as an intermediate biomarker between gene expression and behavioral manifestations. Such a biomarker could be useful in clinical trials as an endpoint or predictor of treatment response. However, seizures and antiepileptic medications also affect resting neural oscillatory activity and could undermine the utility of resting state EEG features as biomarkers in neurodevelopmental disorders such as TSC.

Methods

This paper comp

SUBMITTER: Clements CC 

PROVIDER: S-EPMC11742757 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature