ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice.

ABSTRACT:

Background

Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therapeutic interventions, the underlying mechanisms precipitating the progression of PAD to CLTI remain elusive.

Methods

Considering diabetes is one of the main risk factors contributing to PAD exacerbation into CLTI, we compared hind limb ischemia recovery in HFD STZ vs. non-HFD STZ mice to identify new mechanisms responsible for the exacerbation of PAD.

Results

We used three different mouse models of diabetes and found that blood flow recovery in HFD STZ mice is altered only from day 14

SUBMITTER: Foussard N 

PROVIDER: S-EPMC11742775 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature