Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study.

ABSTRACT:

Background

Lipoid pneumonia (LP) is a rare disease caused by the accumulation of lipids and lipid-laden macrophages in the alveoli inducing damage. LP is difficult to differentiate from other similar diseases without pathological evidence, such as upper respiratory tract infection (URTI), pneumonia, cryptogenic organizing pneumonia (COP), pulmonary alveolar proteinosis (PAP), lung mucinous adenocarcinoma and pulmonary edema. Given the high misdiagnosis rate and limited statistical clinical and treatment data, there is an urgent need for novel indicators of LP. Superoxide dismutase type1 (SOD1) plays an essential role in macrophage polarization, promoting inflammation and oxidative stress, but its association with LP remains unknown.

Methods

The clinical data of 22 patients w

SUBMITTER: Hu Y 

PROVIDER: S-EPMC11742801 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature