Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and destruction of lung tissue, primarily attributed to tobacco smoking. However, other factors like biomass-burning smoke (BS) exposure are also implicated. COPD has been described as an accelerated aging disease, and telomere length is a biomarker of aging.

Methods

This study examined telomere length in 189 Mexican individuals, from which 93 developed COPD secondary to BS exposure (BE-COPD); the rest of the participants were exposed to BS but did not develop the disease. Lung function parameters were measured by spirometry, and relative telomere length (rTL) from peripheral blood DNA was determined using multiplex qPCR.

Results

Results showed rTL to inversely

SUBMITTER: Dominguez-de-Barros A 

PROVIDER: S-EPMC11742994 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature