Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens.

ABSTRACT:

Background

Accurate and comprehensive identification of enteropathogens, causing infectious gastroenteritis, is essential for optimal patient treatment and effective isolation processes in health care systems. Traditional diagnostic techniques are well established and optimised in low-cost formats. However, thorough testing for a wider range of causal agents is time consuming and remains limited to a subset of pathogenic organisms. Metagenomic next-generation sequencing (mNGS) allows the identification of all pathogens in a sample in a single test, without a reliance on culture or introduction of target selection bias. This study aims to determine the ability to routinely apply mNGS testing, in comparison to traditional culture or polymerase chain reaction (PCR) based tests, for th

SUBMITTER: Angel NZ 

PROVIDER: S-EPMC11742996 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature