Development of a Simvastatin-Loaded Copolymer Acid-Sensitive Nanocarrier and Its Experimental Use in the Treatment of Keloids.

ABSTRACT:

Objective

The lipid-lowering simvastatin (SIM) has been shown to be an effective inhibitor of keloid proliferation. However, due to its low water solubility and short half-life, simvastatin aggregates to the liver and does not reach the skin lesions after oral administration, which restricts its widespread clinical use. The development of nanomedicine provides the possibility for us to break through this bottleneck problem clinically. The objective of this study was to investigate the feasibility of using complex nanocontrolled delivery system (CNDS), simvastatin-loaded polyethylene glycol-poly lactic-co-glycolic acid (PEG-PLGA), in the treatment of keloids.

Methods

In the in vitro study, the release of simvastatin in fibroblasts by CNDS@Simvastatin and its effect on inhibit

SUBMITTER: Zhuang BY 

PROVIDER: S-EPMC11743034 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature