Troxerutin Delays Skin Keratinocyte Senescence Induced by Ionizing Radiation Both In Vitro and In Vivo.

ABSTRACT:

Backgrounds

With the increasing demand for beauty and a healthy lifespan, studies regarding anti-skin aging have drawn much more attention than ever before. Skin cellular senescence, the primary cause of skin aging, is characterized by a cell cycle arrest in proliferating cells along with a senescence-associated secretory phenotype (SASP), which can be triggered by various internal or external stimuli.

Aims

Recent studies have made significant progress in the fields of anti-senescence and anti-aging. However, little is known about the roles and functions of natural compounds, particularly flavonoids, in skin cellular senescence studies.

Methods

In this study, using strategies including ionizing radiation (IR), senescence-associated β galactosidase assay (SA-β-Gal), im

SUBMITTER: Chen J 

PROVIDER: S-EPMC11743059 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature