Utilising paired measurements of phosphatidylethanol to monitor early success in alcohol abstinence.

ABSTRACT:

Introduction

Phosphatidylethanol (PEth) is a specific and persisting marker of ethanol (alcohol) consumption. Early success of medically necessary abstinence can be assessed by monitoring PEth disappearance at a biologically plausible rate. This requires an understanding of PEth elimination, its variability and its determinants. To achieve this, we characterised PEth elimination in drinkers who voluntarily abstained. We aimed to derive a nomogram from the data to assist practitioners in recognising abstinence.

Methods

Twenty-nine usual drinkers who were prepared to abstain from alcohol consumption for 4 weeks were recruited. Erythrocyte PEth was measured weekly. A population pharmacokinetic model for PEth was developed, describing the time-course of PEth elimination. Estimat

SUBMITTER: White D 

PROVIDER: S-EPMC11743193 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature