Optimizing the production and efficacy of antimicrobial bioactive compounds from <i>Streptomyces kanamyceticus</i> in combating multi-drug-resistant pathogens.

ABSTRACT:

Background

The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate Streptomyces kanamyceticus from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of bioactive compounds.

Methods

Soil samples were collected from local regions, processed, and analysed for Streptomyces strains isolation using morphological characteristics and molecular identification through 16S rRNA gene PCR assay. Antimicrobial activity was assessed against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Candida albicans using the double-layer method, while Minimum Inhibitory Concentration (MIC) values were determined. The extracted co

SUBMITTER: Shang Z 

PROVIDER: S-EPMC11743287 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature