Mapping functions for the PHQ-9 and GAD-7 to generate EQ-5D-3L for economic evaluation.

ABSTRACT:

Purpose

Generic preferenced-based measures, such as EQ-5D-3L, that are used to estimate quality adjusted life years (QALYs) for economic evaluation are not always available in clinical trials. Predicting EQ-5D-3L values from the commonly used Patient Health Questionnaire 9 (PHQ-9) and Generalised Anxiety Disorder-7 (GAD-7) would allow estimation of QALYs from such trials. The aim was to provide mapping functions to estimate EQ-5D-3L from PHQ-9 and GAD-7 to facilitate economic evaluation.

Methods

Data was drawn from four trials of patients with symptoms of depression testing collaborative care or computerised cognitive behavioural therapy. Patients completed PHQ-9, GAD-7, and EQ-5D-3L at different timepoints. Mapping was undertaken using adjusted limited dependent variable mi

SUBMITTER: Mukuria C 

PROVIDER: S-EPMC11743390 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature