Inhibition of CHI3L1 decreases N-cadherin and VCAM-1 levels in glioblastoma.

ABSTRACT:

Background

The protein CHI3L1 contributes to cancer development by several mechanisms, including stimulation of angiogenesis and invasion as well as immunomodulatory effects. These properties make it a potential target for the development of targeted therapies in precision medicine. In this context, the particular potential of CHI3L1 inhibition could be considered in glioblastoma multiforme (GBM), whose tumors exhibit high levels of angiogenesis and increased CHI3L1 expression. This study aims to investigate whether inhibition of CHI3L1 in spheroids used as a GBM model affects the mechanisms of invasiveness; METHODS: We analyzed the interactions between CHI3L1 and the inhibitor G721-0282 in molecular docking and molecular dynamics (in silico) and infrared spectroscopy. Uptake of G7

SUBMITTER: Rusak A 

PROVIDER: S-EPMC11743419 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature