Age-associated alterations in immune and inflammatory responses in captive olive baboons (Papio anubis).

ABSTRACT:

Introduction

Advanced age is a primary risk factor for many chronic diseases and conditions; however, age-related immune dysregulation is not well understood. Animal models, particularly those that resemble human age-related physiological changes, are needed to better understand immunosenescence and to improve health outcomes. Here, we explore the utility of the olive baboon (Papio anubis) in studying age-related changes to the immune system and understanding mechanisms of immunosenescence.

Methods

We examined immune cell, inflammatory responses, cytokines, and cortisol levels using hematology and flow cytometry, mitogen stimulation, multiplex cytokine assay, and cortisol immunoassay.

Results and discussion

Our results reveal significant age effects on numerous immune

SUBMITTER: Mulholland MM 

PROVIDER: S-EPMC11743478 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature