<i>FiberO</i> for an automated quantitative analysis of fibers orientation and organization in biological fibrous tissues.

ABSTRACT: Many biological fibrous tissues exhibit distinctive mechanical properties arising from their highly organized fibrous structure. In disease conditions, alterations in the primary components of these fibers, such as type I collagen molecules in bone, tendons, and ligaments, assembly into a disorganized fibers architecture generating a weak and/or brittle material. Being able to quantitatively assess the fibers orientation and organization in biological tissue may help improve our understanding of their contribution to the tissue and organ mechanical integrity, and assess disease progress and therapy effect. In this work, we present FiberO, a new open-source available software that automatically quantifies fibers orientation, by performing morphological image openings, and fibers orga

SUBMITTER: Munoz A 

PROVIDER: S-EPMC11743555 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature