Preliminary experimental study on a novel device using biomaterial for shunting fibrotic bleb following Ahmed glaucoma valve surgery in dogs.

ABSTRACT: This study aimed to design and evaluate a novel trans-bleb device (TBD) for draining aqueous humor trapped within fibrotic blebs following Ahmed glaucoma valve (AGV) implantation in dogs. Two clinically normal, purpose-bred Beagles underwent AGV implantation surgery in one eye. When a bleb was formed with increased intraocular pressure (IOP), the TBD was inserted through a fenestration created in the bleb. IOP measurements, slit-lamp biomicroscopic and ultrasound biomicroscopic (UBM) evaluations were performed during follow-up. Results showed that IOP in the eyes undergoing AGV surgery was significantly lower than in the contralateral normal eye (P < .001). After 3 weeks, the IOP increased, and the UBM examination confirmed the presence of a bleb wall and an underlying cavity. After TBD ap

SUBMITTER: Lee S 

PROVIDER: S-EPMC11743597 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature