Ammonia and hydrogen sulfide - new insights into gut microbiota and male infertility through meta-analysis.

ABSTRACT:

Background

Ammonia (NH₃) and hydrogen sulfide (H₂S) are produced during digestion in the human gut, yet the impact of these internally generated gases on male reproduction have received limited attention in scientific research.

Methods

We systematically reviewed 935 scientific publications, spanning from 1947 to 2023, focusing on external or internal NH₃ and/or H₂S, male infertility, and gut microbiota. Meta-analysis was conducted to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs) of combined studies.

Results

Our findings revealed that the internal NH₃ and/or H₂S were negatively related to the Lactobacillus, which is beneficial to male fertility, whereas NH₃

SUBMITTER: Hao Y 

PROVIDER: S-EPMC11743720 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature