Association between gut microbiome profiles and host metabolic health across the life course: a population-based study.

ABSTRACT:

Background

The human gut microbiome changes considerably over time. Previous studies have shown that gut microbiome profiles correlate with multiple metabolic traits. As disease development is likely a lifelong process, evidence gathered at different life stages would help gain a better understanding of this correlation. Therefore, we aim to investigate how the association of the gut microbiome and metabolic traits change over the lifespan.

Methods

We identified microbiome patterns (clusters) within two population-based cohorts at different life stages, i.e., pre-adolescents of the Generation R Study (mean age 9.8 years; n = 1488) and older adults of the Rotterdam Study (RS, mean age 62.7 years; n = 1265) using K-Means clustering, and surveyed for host metabolic phenotypes,

SUBMITTER: Li R 

PROVIDER: S-EPMC11743806 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature