Reversible Ca²⁺ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads.

ABSTRACT: Ultrasound and microbubble mediated blood brain barrier opening is a non-invasive and effective technique for drug delivery to targeted brain region. However, the exact mechanisms are not fully resolved. The influences of Ca²⁺ signaling on sonoporation and endothelial tight junctional regulation affect the efficiency and biosafety of the technique. Therefore, an improved understanding of how ultrasound evokes Ca²⁺ signaling in the brain endothelial monolayer, and its correlation to endothelial permeability change is necessary. Here, we examined the effects of SonoVue microbubbles or integrin-targeted microbeads on ultrasound induced bioeffects in brain microvascular endothelial monolayer using an acoustically-coupled microscopy system, where focused ultrasound exposur

SUBMITTER: Lin J 

PROVIDER: S-EPMC11743859 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature