The role of the gut microbiota and the nicotinate/nicotinamide pathway in rotenone-induced neurotoxicity.

ABSTRACT: Rotenone is a natural compound from plants. It is widely used in pesticides because of highly toxic to insects and fish. However, lots of research has reported that rotenone has neurotoxic effects in humans. It is confirmed there is a correlation between rotenone exposure and Parkinson's disease (PD). Therefore, the role of gut microbiota and related metabolic pathways was investigated in rotenone-induced neurotoxicity. The results showed that the abundance of gut microbiota changed significantly. The differential metabolites were enriched in the nicotinate and nicotinamide metabolism pathways, which had the greatest impact on the entire metabolic system. The contents of acetic acid and butyric acid in intestinal tissues decreased significantly. Additionally, Interleukin-6 (IL-6), Tumor ne

SUBMITTER: Sai Y 

PROVIDER: S-EPMC11743872 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature