Impact of a national HPV vaccination programme for preadolescent girls on cytology screening performance and CIN2+ incidence: five-year population-based cervical screening results from Slovenia.

ABSTRACT:

Background

HPV vaccination is most efficacious in preventing cervical cancer and its precursors when administered during preadolescence. Because in Slovenia women are invited for cytology screening from age 20, women targeted for preadolescent HPV vaccination have been screening-eligible since 2018. We aim to assess the impact of preadolescent HPV vaccination programme on cytology screening performance and CIN2+ incidence.

Methods

This is a cohort study using data from Slovenia's cervical screening registry. We compared the incidence of high-grade lesions (CIN2 or worse) between women in the first vaccine-targeted birth cohort (1998-2001) and in the latest non-vaccine-targeted birth cohort (1994-1997). We calculated the Incidence Rate Ratio (IRR) of CIN2+ using Poisson regre

SUBMITTER: Irzaldy A 

PROVIDER: S-EPMC11743916 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature