Effects of Muse Cell on a Mouse Model With Acute Encephalopathy.

ABSTRACT:

Introduction

Acute encephalopathy (AE) in childhood due to a viral infection causes convulsions and altered consciousness, leading to severe sequelae and death. Among the four types of AE, cytokine storm-induced AE is the most severe and causes serious damage to the brain. Moreover, a fundamental treatment for AE has not been established yet. Recently, it has been shown that the administration of multilineage-differentiating stress-enduring (Muse) cells, a population of mesenchymal stem cells, improves symptoms in various types of brain injuries when administered in the subacute phase (1-7 days after brain damage). We aimed to examine the effects of Muse cells in a cytokine storm-induced AE animal model using immunocompromised nonobese diabetic/severe combined immunodeficiency (NOD

SUBMITTER: Kawaguchi T 

PROVIDER: S-EPMC11743977 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature