Age and Sex-Related Differences in Neuroprotective Effects of Cardiovascular Endurance on Cortical Thickness and Brain Volume in Adults Across Age.

ABSTRACT:

Background

Higher cardiorespiratory fitness and cardiovascular endurance (CE) have been shown to be neuroprotective in older adulthood, but the mechanisms underlying this neuroprotection across the adult lifespan are poorly understood. The current study sought to examine the neuroprotective effects of CRF on gray matter (GM) and white matter (WM) volumes, and mean cortical thickness (MCT), using a large sample across the adult lifespan. We also examined sex differences in these relationships.

Methods

This cross-sectional study included data from 1691 adults across the adult lifespan (22-100 years) from the Human Connectome Project Young Adults and Aging data. 2-minute walk test performance was used as a proxy of CE. Structural MRI was used to assess total GM volume, WM volum

SUBMITTER: Won J 

PROVIDER: S-EPMC11743984 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature