Causal Relationship Between Emotional Disorders and Thyroid Disorders: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT:

Introduction

The interplay between emotional disorders and thyroid disorders has been subject to numerous observational studies, which have consistently reported associations but have failed to establish clear causal links due to the multifactorial etiology and influences. We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to explore the genetic causal association between emotional disorders and thyroid disorders.

Methods

We employed several methods, including inverse-variance weighted (IVW), weighted median, weighted mode, and MR Egger regression. Additionally, sensitivity analyses were conducted using MR-Egger, MR Pleiotropy Residual Sum and Outlier (MR-PRESSO), Cochran's Q, and leave-one-out methods.

Results

IVW results showed negative ca

SUBMITTER: Fan J 

PROVIDER: S-EPMC11743992 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature