Basolateral amygdala volume in affective disorders using 7T MRI <i>in vivo</i>.

ABSTRACT:

Background

The basolateral complex of the amygdala is a crucial neurobiological site for Pavlovian conditioning. Investigations into volumetric alterations of the basolateral amygdala in individuals with major depressive disorder (MDD) have yielded conflicting results. These may be reconciled in an inverted U-shape allostatic growth trajectory. This hypothesized trajectory unfolds with an initial phase of volumetric expansion, driven by enhanced dendritic arborization and synaptic plasticity. The increase in volume is followed by a reduction phase, as glucocorticoid exposure cumulatively results in excitotoxic damage, reflecting allostatic load.

Methods

7T magnetic resonance brain imaging was conducted on a total of 84 participants (mean age 38 ± 12 years), comprising 20 unm

SUBMITTER: Kurzinger B 

PROVIDER: S-EPMC11744004 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature