Activation of Evolutionarily Young Endogenous Retroviruses Is Implicated in COVID-19 Immunopathology.

ABSTRACT: The dysfunction of the innate immune system is well-described as a clinical characteristic of COVID-19. While several groups have reported human endogenous retroviruses (ERVs) as enhancing factors of immune reactivity, characterization of the COVID-19-specific ERVs has not yet been sufficiently conducted. Here, we revealed the transcriptome profile of more than 500 ERV subfamilies and innate immune response genes in eight different cohorts of platelet, peripheral blood mononuclear cells (PBMCs), lung, frontal cortex of brain, ventral midbrain, pooled human umbilical vein endothelial cells (pHUVECs), placenta, and cardiac microvascular endothelial cells (HCMEC) from COVID-19 patients (total; n = 124) and normal samples (total; n = 53) using publicly available datasets. While upregulation of

SUBMITTER: Yoshida R 

PROVIDER: S-EPMC11744038 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature