Assessment of intratumor heterogeneity for preoperatively predicting the invasiveness of pulmonary adenocarcinomas manifesting as pure ground-glass nodules.

ABSTRACT:

Background

The increased use of low-dose computed tomography (CT) for lung cancer screening has improved the detection of ground-glass nodules. However, as the clinical utility of CT findings to predict the invasiveness of pure ground-glass nodules (pGGNs) is currently limited, differentiating pGGNs that indicate invasive adenocarcinoma (IAC) from those that represent other histological entities is challenging. We aimed to quantify intratumor heterogeneity of lung adenocarcinomas characterized by pGGNs on CT to assess its efficacy in predicting IACs before surgery.

Methods

Overall, 575 patients with persistent pGGNs and a postoperative pathological diagnosis of lung adenocarcinoma were included. To quantitatively measure intratumor heterogeneity, an intratumor heterogeneity

SUBMITTER: Qi H 

PROVIDER: S-EPMC11744125 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature