Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.

ABSTRACT:

Background

It is well known that dysfunction of thalamocortical circuity generates the motor signs that lead to distinct disease processes and prognoses in Parkinson's disease (PD). This study aimed to leverage ultrahigh-field magnetic resonance imaging (MRI) to identify the connectivity alterations of thalamocortical circuity and clarify their relation to motor signs in early PD.

Methods

Patients with early-stage PD (n=55) and healthy controls (HCs, n=56) were recruited from March 2022 to July 2023. All participants underwent 7-Tesla MRI scans as the baseline. Sign scores were calculated from the Movement Disorder Society Unified Parkinson's Disease Rating Scale III. Significant differences in the functional connectivity between the thalamus subregions and cortex between th

SUBMITTER: Wang X 

PROVIDER: S-EPMC11744139 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature