Application of low-dose FDG-PET/MRI for quantification of lung changes in pediatric patients with cystic fibrosis: a new inflammatory index.

ABSTRACT:

Background

Clinical severity and progression of lung disease in cystic fibrosis (CF) are significantly influenced by the degree of lung inflammation. Non-invasive quantitative diagnostic tools are desirable to differentiate structural and inflammatory lung changes in order to help prevent chronic airway disease. This might also be helpful for the evaluation of longitudinal effects of novel therapeutics. Therefore, the present study assesses the quantification of inflammatory lung changes using positron emission tomography/magnetic resonance imaging (PET/MRI) of the lung in children and adolescents with CF and evaluates the possible impact of PET/MRI on individualized therapy management.

Methods

This monocentric, retrospective cohort study included 19 PET/MRI of the lung perf

SUBMITTER: Schwarz R 

PROVIDER: S-EPMC11744157 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature