Plasma amino acid profiles of dogs with the hepatocutaneous syndrome and dogs with other chronic liver diseases.

ABSTRACT:

Background

Dogs with hepatocutaneous syndrome (HCS) have marked plasma hypoaminoacidemia, but its occurrence in dogs with chronic liver diseases not associated with HCS (non-HCS CLD) is unknown.

Objectives

To determine if plasma hypoaminoacidemia occurs in dogs with non-HCS CLD, compare plasma amino acid (PAA) profiles between dogs with non-HCS CLD and HCS, and define a sensitive and specific PAA pattern for diagnosing HCS.

Animals

Data were collected from client-owned dogs, a prospective cohort of 32 with CLD and 1 with HCS, and a retrospective cohort of 7 with HCS.

Methods

Prospective study. Dogs with chronic serum liver enzyme increases were recruited after hepatic biopsy. Plasma amino acid profiles were measured using high-performance liquid chromatography.

SUBMITTER: Leela-Arporn R 

PROVIDER: S-EPMC11744303 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature