Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications.

ABSTRACT:

Background

Immunomodulatory agents targeting the CD11d/CD18 integrin are in development for the treatment of several pathophysiologies including neurotrauma, sepsis, and atherosclerosis. Murine anti-human CD11d therapeutic antibodies have successfully improved neurological and behavioral recovery in rodent neurotrauma models. Here, we present the progression of CD11d-targeted agents with the development of humanized anti-CD11d monoclonal antibodies.

Methods

Primary human leukocytes and the THP-1 monocytic cell line were used to determine the binding of the CD11d antibodies, determine binding affinities, and assess outside-in signaling induced by CD11d antibody binding. In addition, a rat model of spinal cord injury was employed to demonstrate that the humanized monoclonal an

SUBMITTER: Blythe EN 

PROVIDER: S-EPMC11744312 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature