Association between peri-operative red blood cell transfusion and cancer recurrence in patients undergoing major cancer surgery: an umbrella review.

ABSTRACT:

Introduction

Peri-operative allogeneic red blood cell transfusion is hypothesised to increase the risk of cancer recurrence following cancer surgery. However, previous data supporting this association are limited by residual confounding. We conducted an umbrella review (i.e. a systematic review of systematic reviews) to synthesise and evaluate the evidence between red blood cell transfusion and cancer recurrence.

Methods

We searched online databases for systematic reviews of red blood cell transfusion and cancer-related outcomes. The AMSTAR 2 tool was used for quality assessment. The adequacy of confounding adjustment was judged according to a consensus-derived framework.

Results

We included five relevant systematic views which included patient populations ranging fro

SUBMITTER: Etheridge J 

PROVIDER: S-EPMC11744431 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature